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5 OMIM references -
4 associated genes
11 signs/symptoms

COMMON GENES: 1

Meacham syndrome

1 OMIM reference -
1 associated gene
22 signs/symptoms

Nephroblastoma

Meacham syndrome

DIS3L2	(UniProt - OMIM)		WT1	(UniProt - OMIM)
H19	(OMIM)
POU6F2	(UniProt - OMIM)
WT1	(UniProt - OMIM)


COMMON GENES	WT1

Citations in the biomedical literature:

Nephroblastoma		Meacham syndrome
	Synonym(s): - Renal embryonic tumor - Wilms tumor		Synonym(s): - Meacham-Winn-Culler syndrome - Rhabdomyomatous dysplasia - cardiopathy - genital anomalies

	Classification (Orphanet): - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare gynecologic or obstetric disease - Rare urogenital disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 5 OMIM references - 1 MeSH reference: D009396		External references: 1 OMIM reference - No MeSH references

Nephroblastoma		Meacham syndrome
	Very frequent - Acute abdominal pain / colic - Kidney / renal neoplasm / tumor / carcinoma / cancer - Neoplasms / tumors Occasional - Aniridia / iris hypoplasia - Chronic arterial hypertension - Fever / chilling - Hematuria / microhematuria - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Lymphadenopathy / polyadenopathies - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Ambiguous genitalia - Diaphragmatic hernia / defect / agenesis - Hypoplastic lungs / pulmonary hypoplasia / agenesis - Uterine / uterus / Fallopian tubes anomalies - Vagina anomalies / atresia / hydrometrocolpos / hymen imperforation Frequent - Absent lobe / lung / segmentation defect / abnormal lobulation / sequestration - Death in infancy - Hypoplastic left heart / ventricle - Micropenis / small penis / agenesis - Stillbirth / neonatal death - Structural and functional anomalies of the spleen - Undescended / ectopic testes / cryptorchidia / unfixed testes Occasional - Anomalous pulmonary venous return - Asplenia / polysplenia / spleen lobulation / accessory spleen - Atrial septal defect / interauricular communication - Dextrocardia / abnormal heart position / cardiac heterotaxia / situs inversus - Ectopic / horseshoe / fused kidneys - Hypoplastic aorta / coarctation / stenosis / anomaly / aortic arch interruption - Patent ductus arteriosus - Tetralogy of Fallot / trilogy of Fallot - Transposition of great vessels - Ventricular septal defect / interventricular communication